Inclusion Criteria:

- Women aged from 18 to 35

- Infertility for a period of a year or more or 6 month of irregular menstrual cycle

- PCOS under the Rotterdam criteria

- Insulin resistance HOMA-IR > 2.5

- Normal semen analysis values

- Normal values of the following blood analysis: FSH, LH, Estradiol, AMH, TSH,
Prolactine, Fasting glucose level, hemoglobin A1C, AST, ALT, alkaline phosphatase,
SHBG, 17OH progesterone, DHEAS, Androstenedione, total testosterone, LDL, HDL, total
cholesterol, Triglycerides, oral glucose tolerance test

Exclusion Criteria:

- Tubular factor

- Normal ovarian reserve

- Prior use of CC or Metformin, hypoglycemic agents, glucocorticoids, anti-androgen,
weight-loss agent or oral contraceptives in the past 6 months

- Neoplasia

- BMI > 35

- Renal, hepatic or cardiac failure

- Lactic, acidosis antecedent