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The Thai Red Cross AIDS Research Centre

18 Years
90 Years
Not Enrolling
Anal Intraepithelial Neoplasia

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Trial Information

The Thai Red Cross AIDS Research Centre

The goals of this application are to assess the usefulness of biomarkers, including p16
proteins, MCM proteins, high-risk HPV types, and E6 and E7 mRNA/oncoproteins, as adjunct
tools to anal Pap smear in identifying HGAIN and to study the impact of HIV infection on the
characteristics of anal cytology (by anal Pap smear) and biomarkers. To fulfill these goals,
in addition to routine practice, it will be necessary to follow 450 MSM (315 HIV-positives
and 135 HIV-negatives) over 60 months, and perform HRA and biomarkers on all clients at
baseline and every 12 months. Information from this study would inform AIN screening and
follow up approaches in HIV-positive and HIV-negative MSM in both resource-limited and
resource-rich settings.

Inclusion Criteria:

- MSM with HIV negative

- MSM with HIV positive

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective


Thailand: Ethical Committee

Study ID:

AIN Study



Start Date:

December 2009

Completion Date:

Related Keywords:

  • Anal Intraepithelial Neoplasia
  • Histological HGAIN
  • detected biomarkers
  • MSM population
  • HPV subtypes
  • AIN study
  • HIV-positive and HIV-negative MSM
  • anal cytology and biomarkers
  • likelihood of AIN development at month 12 and yearly thereafter
  • Neoplasms
  • Carcinoma in Situ