Prospective Randomized Trial of Hypofractionated Radiotherapy Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children.
In lack of open study protocols aiming to increase cure rate in pediatric diffuse intrinsic
pontine glioma (DIPG), the investigators examined a hypofractionated radiotherapy regimen up
to a dose of 39Gy in 13 fractions, completed in 2.5-3 weeks, instead of 6 weeks.
This schedule offers a reduction in patient burden, especially preferable in children with a
poor compliance and performance status. The non-inferiority of the hypofractionated regimen
in its clinical end-results, with the reduction of the overall treatment time to less than
its half will decrease the burden for the patient, his/her family and the treating
department. This will be considered as added value without compromising the survival or
increasing side effects.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Median overall-free survival
Mohamed s zaghloul, MD
Children's Cancer Hospital Egypt 57357
Egypt: Institutional Review Board