The Effect of a Meal on Brain Activation in Reward Pathways
Potential subjects will participate in a short phone screening interview and if eligible,
will come to the University of Washington hospital 2 times. At the first health screening
visit, we will go over the subjects' medical history, weight and height, and eating habits.
This visit will take an hour or so and eligible subjects will then schedule the study visit.
For the study visit, subjects will have to fast overnight from 9:30 pm the night before and
arrive at the hospital at 8:00am. At 8:30 am, the subject will have a 30 minute MRI scan of
the brain done in the University of Washington Radiology Department. During the MRI scan
they will see pictures of common objects and foods and be asked to remember the photos they
saw. At 9 am subjects will eat a standard breakfast, and they will not eat again until after
the second MRI. The time of their second MRI will be randomly assigned to one of seven time
points anywhere from 15 minutes to 5 hours after the breakfast. After the MRI, subjects will
be allowed to eat freely from food we provide. Subjects will receive $10 for the health
screening visit, and $50-85 depending on the length of the visit.
Observational Model: Case Control, Time Perspective: Cross-Sectional
BOLD response as measured by brain fMRI during viewing of food photographs
To determine whether the change in brain response (as captured by MRI) to visual food cues with food intake is a marker of satiety. We hypothesize that consumption of a meal will reduce brain activation by food cues and that these reductions will be temporally associated with both subjective and objective measures of satiety.
We will randomly assign subjects to one of 7 timepoints for a post-meal brain MRI - 15, 30, 60, 120, 180, 240, or 300 minutes after their breakfast.
Ellen Schur, MD, MS
United States: Institutional Review Board
|University of Washington Medical Center||Seattle, Washington 98195-6043|