Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors
I. To develop the instrumentation to achieve real time processing and display of
intraoperative 2-dimensional optical imaging and spectroscopy (i2DOS) maps in the operating
II. To examine the timing and spatial involvement of human cortex intraoperatively to
different stimuli using i2DOS.
OUTLINE: Patients undergo i2DOS.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Determination of the effectiveness of intraoperative optical imaging technology and optical spectroscopy.
Optical reflectance images will be analyzed by pixel by-pixel subtraction of a control trial and a stimulation trial. This subtracted image will then be divided by the control image to normalize for differences between subjects and trials. These ratios thus represent proportional changes from baseline.
Day 1 post surgery
Neal Prakash, MD, PhD
City of Hope Medical Center
United States: Institutional Review Board
|City of Hope Medical Center||Duarte, California 91010|