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Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors

18 Years
Open (Enrolling)
Brain Tumor

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Trial Information

Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors


I. To develop the instrumentation to achieve real time processing and display of
intraoperative 2-dimensional optical imaging and spectroscopy (i2DOS) maps in the operating

II. To examine the timing and spatial involvement of human cortex intraoperatively to
different stimuli using i2DOS.

OUTLINE: Patients undergo i2DOS.

Inclusion Criteria:

- Neurosurgical patient population in the City of Hope brain and spinal tumor
neurosurgical programs that have been diagnosed with a brain tumor.

- Only lucid patients qualified to consent to neurosurgical procedure will be
approached for participation in this study.

- We do intend to enroll subjects with potentially terminal brain tumors. Due to the
potential benefit of intraoperative mapping, we are not planning to exclude these

- Patients with any type of brain tumor will be eligible for participation.

- All subjects must have the ability to understand and the willingness to sign a
written informed consent.

Exclusion Criteria:

- There are no exclusion criteria except for individuals without a brain tumor and the
location of the craniotomy. If the exposed area of brain is not compatible with
peripheral stimuli or volitional activity the subject cannot be enrolled.

- Subjects, who in the opinion of the investigator, may not be able to comply with the
safety monitoring requirements of the study.

Type of Study:


Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Determination of the effectiveness of intraoperative optical imaging technology and optical spectroscopy.

Outcome Description:

Optical reflectance images will be analyzed by pixel by-pixel subtraction of a control trial and a stimulation trial. This subtracted image will then be divided by the control image to normalize for differences between subjects and trials. These ratios thus represent proportional changes from baseline.

Outcome Time Frame:

Day 1 post surgery

Safety Issue:


Principal Investigator

Neal Prakash, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

City of Hope Medical Center


United States: Institutional Review Board

Study ID:




Start Date:

May 2013

Completion Date:

Related Keywords:

  • Brain Tumor
  • Brain Tumor
  • Brain Neoplasms



City of Hope Medical CenterDuarte, California  91010