Identifying and Validating Novel Mechanisms of Radiation Resistance in Rhabdomyosarcoma
N/A
N/A
Both
Sarcoma
Trial Information
Identifying and Validating Novel Mechanisms of Radiation Resistance in Rhabdomyosarcoma
OBJECTIVES:
- Determine the molecular response/resistance signatures with radiotherapy and standard
chemoradiation treatments using the xenograft model of the Pediatric Preclinical
Testing Program (PPTP).
- Validate these novel pathways/biomarkers by their detection within clinically annotated
patient tumor tissue samples and testing their associations with clinical response,
local control rates, and overall survival rates.
OUTLINE: Archived tissue samples of matched primary-relapsed and non-matched primary are
analyzed for genomic DNA, DNA methylation profiles, RNA sequencing, differences between
alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS), gene expression
profiles, target-of-rapamycin complex 1 (TORC1) and TORC2 pathway intermediates, and paired
box 3 (PAX3)/forkhead box O1 (FOXO1) translocation by microarray, immunohistochemical
staining, and fluorescence in situ hybridization (FISH).
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Tissues requested from the Children Oncology Group (COG) sarcoma banking protocol
COG-D9902
- All subtypes of rhabdomyosarcoma specimens
- Matched primary-relapsed specimens (from same patient, separated by time):
- Frozen tissue if available
- Scrolls of formalin-fixed paraffin-embedded tissue (if frozen not
available)
- 10 unstained formalin-fixed paraffin-embedded thin sections
- All other general (primary or relapsed) cases
- 10 unstained formalin-fixed paraffin-embedded thin sections
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Molecular response/resistance signatures of radiotherapy and standard chemoradiation using Spearman's rho
Safety Issue:
No
Principal Investigator
Christopher E. Pelloski, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Ohio State University Comprehensive Cancer Center
Authority:
United States: Federal Government
Study ID:
CDR0000735399
NCT ID:
NCT01626170
Start Date:
June 2012
Completion Date:
Related Keywords:
- Sarcoma
- alveolar childhood rhabdomyosarcoma
- embryonal childhood rhabdomyosarcoma
- previously untreated childhood rhabdomyosarcoma
- recurrent childhood rhabdomyosarcoma
- previously treated childhood rhabdomyosarcoma
- Rhabdomyosarcoma
- Sarcoma
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