An Imaging Study to Compare Methods to Reduce 4DCT Image Acquisition Artifacts
By using 4D CT scans, researchers can create images that show how air moves through the
lungs. This new method to check lung function may make better images than the standard
methods. Researchers will compare 4 images of how air moves through your lungs and 1 image
while you hold your breath.
If you are found to be eligible to take part in this study (if the screening test is
applicable) and you agree to take part in this study, you will be enrolled in 1 of 2 study
groups, depending on when you join the study. There will be up to 18 participants in each
group. In the first group, researchers will test several different methods to create images
of how air moves through the lungs. Researchers will then select the most successful
methods from the first group and try to do them again with the second group.
You will have 1 visit for this study. At this visit, you will have 4 (or 3 for Group 2) 4D
CT scans performed while you are breathing normally. You will also have 1 scan while you
hold your breath for less than 20 seconds. The CT scans will take about 5 minutes each to
The 4D CT scan will cover the entire chest area using the standard dose of radiation. A
2-inch plastic box will be placed on top of your chest to track the motion of your chest
while you breathe during each scan. Some parts of your chest will be scanned up to 2 more
times based on your breathing.
The entire scanning session will take about 45 minutes to complete.
Length of Participation:
Your active participation on the study will be over when you have completed your study
Follow-Up Phone Call:
Within 7 days after your study visit, the study staff will call you to ask about any side
effects you may be having. This call should last about 2 minutes.
If anything unusual is found in the imaging, your cancer doctor will be told so that you can
This is an investigational study. The CT scans used in this study are delivered using
FDA-approved and commercially available systems. Creating images of how air moves through
the lungs from 4D CT scans is considered investigational.
Up to 36 patients will take part in this study. All will be enrolled at M. D. Anderson.
Observational Model: Cohort, Time Perspective: Prospective
Patient Percentage with 4DCT Acquisition Artifacts
Primary statistical analysis is intra-subject comparison of artifacts versus acquisition methods. In cohort 1: 4DCT acquisition techniques consist of 1) baseline acquisition, 2) extended acquisition, 3) real-time acquisition gating, and 4) re-imaging of bad segments. An automated computer scoring system, as described by Han et al., will be implemented and validated using the first 5 cases. To quantify 4DCT image quality, number and anatomic misplacement distance of artifacts will be measured, for each set of acquisition methods and each subject.
Thomas Guerrero, MD,PHD
UT MD Anderson Cancer Center
United States: Institutional Review Board
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