Molecular Taxonomy of Pediatric Cancer
N/A
21 Years
Both
Leukemia
Trial Information
Molecular Taxonomy of Pediatric Cancer
OBJECTIVES:
- To identify global changes in the epigenome and various underlying histone
modifications that characterize relapsed acute lymphoblastic leukemia (ALL).
- To identify specific transcription factor-binding sites associated with histone
alterations.
- To correlate gene expression changes of differentially regulated genes at relapse with
underlying chromatin modifications.
OUTLINE: Archived bone marrow samples, collected at the time of diagnosis and relapse, are
analyzed for gene expression and histone modifications by microarray, chromatin
immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction
(qRT-PCR).
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of B-cell acute lymphoblastic leukemia
- Paired diagnosis-relapse primary patient samples obtained from the Children's
Oncology Group (COG) cell bank
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Cellular origins of relapse and the underlying epigenetic mechanisms associated with drug resistance
Safety Issue:
No
Principal Investigator
William L. Carroll, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
NYU Clinical Cancer Center
Authority:
United States: Federal Government
Study ID:
CDR0000735342
NCT ID:
NCT01625143
Start Date:
June 2012
Completion Date:
Related Keywords:
- Leukemia
- recurrent childhood acute lymphoblastic leukemia
- untreated childhood acute lymphoblastic leukemia
- B-cell childhood acute lymphoblastic leukemia
- Leukemia
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
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