Molecular Taxonomy of Pediatric Cancer
- To identify global changes in the epigenome and various underlying histone
modifications that characterize relapsed acute lymphoblastic leukemia (ALL).
- To identify specific transcription factor-binding sites associated with histone
- To correlate gene expression changes of differentially regulated genes at relapse with
underlying chromatin modifications.
OUTLINE: Archived bone marrow samples, collected at the time of diagnosis and relapse, are
analyzed for gene expression and histone modifications by microarray, chromatin
immunoprecipitation (ChIP) sequencing, and quantitative real-time polymerase chain reaction
Cellular origins of relapse and the underlying epigenetic mechanisms associated with drug resistance
William L. Carroll, MD
NYU Clinical Cancer Center
United States: Federal Government