Trial Information

Concentration of S-1 Metabolites in Tear and Plasma and Correlation With Its Side Effects in Patients Receiving S-1 Adjuvant Chemotherapy

1. S-1 metabolites concentration in plasma

1. factors affecting plasma concentration

- surgery subtype

- serum creatinine

2. systemic adverse effects of S-1 and its correlation with plasma S-1 metabolites
concentration

- enteritis

- fatigue

2. S-1 metabolites concentration in tears

1. correlation of tear concentration with plasma concentration

2. lacrimal drainage obstruction caused by S-1 administration, and its correlation
with tear S-1 metabolites concentration

3. lacrimal drainage obstruction caused by S-1 administration, and its correlation
with plasma S-1 metabolites concentration