Observational Model: Cohort, Time Perspective: Retrospective
Define the C/EBPa-Bmi-1 axis in human lung cancer
Tissue microarrays will be created from the lung tumours. Only resection specimens will be used for TMA construction, and small, limited biopsies will not be used. Tissue punches of 1.5mm in diameter will be cut from the blocks (2 punches per tumour, 1 punch for normal lung). Hence the rest of the tumour block is not used, preserving most of the tumour tissue in the tissue blocks, for future diagnostic use.
Singapore: Domain Specific Review Boards