Inclusion Criteria:

- To be verified at Visit one and confirmed at Visit two

- Male or female patients aged 18-80 years

- Signs and symptoms consistent with Nelson's Syndrome

- Biochemistry consistent with Nelsons syndrome: failure to suppress plasma ACTH to
less than 200 pg/ml at 2 hours following morning dose of hydrocortisone

- Negative pregnancy test where applicable

Exclusion Criteria:

- Received any prior or current treatment with a pasireotide or other somatostatin
analogue.

- Requires surgery for recent significant deterioration in visual fields or other
neurological signs related to tumour mass.

- Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent
hepatitis, or persistent ALT, AST, alkaline phosphates 2X> upper limit of normal, or
total bilirubin 1.5X> upper limit of normal.

- Patients with symptomatic cholelithiasis

- Abnormal clinical laboratory values considered by the Investigator to be clinically
significant and which could affect the interpretation of the study results

- QTcF interval as measured by ECG >480msecs

- Any current or prior medical condition that may, in the opinion of the Investigator,
interfere with the conduct of the study or evaluation of the results.

- Female patients who are pregnant or lactating, or of childbearing potential and not
practising a medically acceptable method of birth control. Medically acceptable
methods include including the oral contraceptive pill, intrauterine devices,
mechanical methods (e.g. vaginal diaphragm, vaginal sponge, or condom with permicidal
jelly).

- History of alcohol or drug abuse in the sixmonth period prior to Visit 1, or who plan
to take an investigational

- History of alcohol or drug abuse in the six month period prior to Visit 1, or who
plan to take an investigational drug for another study during this study.

- History of noncompliance to medical regimes or who are considered potentially
unreliable.

- Pituitary radiotherapy within the last 1 year prior to study entry.

- Unable to complete the entire study for any reason.