Inclusion Criteria:

- Histologic diagnosis of nasopharyngeal carcinoma

- Distance metastasis at least 6 months after radical treatment

- Not suitable for local treatment, e.g. surgery, TACE

- At least one measurable lesion

- Estimate survival ＞3months

- Range from 18～70 years old

- PS 0~1

- WBC count ≥ 4×109/L，Hemoglobin ≥ 100g/L， platelet count ≥ 100×109/L

- ALT or AST ＜ 2.5×ULN、bilirubin ＜ 1.5×ULN

- 0Serum creatinine ＜ 1.5×ULN

Exclusion Criteria:

- Central nervous system metastases

- Suitable for local treatment

- Second malignancy within 5 years

- Precious therapy with an investigational agent

- Uncontrolled seizure disorder or other serious neurologic disease

- ≥ Grade Ш allergic reaction to any drug including in this study

- Clinically significant cardiac or respiratory disease

- Creatinine clearance < 30ml/min

- Drug or alcohol addition

- Do not have full capacity for civil acts

- Severe complication, active infection

- Concurrent immunotherapy or hormone therapy for other diseases

- Pregnancy or lactation