Inclusion Criteria:

- Histologically confirmed prostate cancer

- Locally operable tumor

- Negative bone scan (obligatory if Gleason Score > 7 or PSA > 20ng/ml

- Karnofsky ≥ 80%

- Age 18 - 75 years

- Informed consent in written form

- Sufficient hematologic, coagulatory and renal function

- Compliant patient and geographic precondition for adequate follow-up given

Exclusion Criteria:

- Manifest secondary tumor

- Organ metastases on CT-scan /MRI or in Histology

- Myocardial infarction or stroke within the last 6 months

- Severe cardiovascular (Grade III - IV according to NYHA), pulmonary (pO2 < 60 mmHg),
renal, hepatic oder hematopoetic impairment

- Severe active or chronic infection (z.B. pos. HIV-Antibody-Test, HBs-Ag-detected in
Serum and/ or chronic Hepatitis)

- Severe psychiatric disease

- Previous chemotherapy

- Previous pelvine radiotherapy