Trial Information

Monitoring the Response of Osteosarcoma Under Neoadjuvant Chemotherapy: The Value of Dynamic Contrast Enhancement and Diffusion-weighted MRI

Dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging have the
potential to measure early cellular and vascular changes that occur in response to
chemotherapy and could therefore be early predictors of therapeutic response.

Aim of our study is to assess the accuracy of dynamic contrast enhanced and
diffusion-weighted MR imaging in evaluating response to chemotherapy during the
preoperative treatment of osteosarcoma. Patients will undergo dynamic contrast-enhanced and
diffusion-weighted magnetic resonance imaging before, during and after chemotherapy.

Our long-term goal is to use these imaging techniques to develop non-invasive methodologies
that would be better predictors of tumor response than the current clinical standard and
earlier predictors than histological evaluation of the whole tumor.