Characterization of Urinary Metabolite Profiles in Wilms Tumor
- To characterize the urinary metabolite signature of 10 stage III, favorable-histology,
Wilms tumor patients from the Cooperative Human Tissue Network (CHTN) Databank, as
distinct from 10 normal controls.
- To characterize and compare the urinary metabolite profile in 50 randomly selected,
stage III, favorable-histology, Wilms tumor patients enriched with an additional 30
stage III Wilms tumor patients who have relapsed.
- To establish if the potential poor outcome (defined as relapse) in the
favorable-histology group has a specific metabolite signature.
- To characterize the urinary metabolite signature of Wilms tumor in patients with
unfavorable histology (diffuse anaplasia) and compare it to those with favorable
OUTLINE: Archived urine samples are analyzed for specific metabolite patterns by nuclear
magnetic resonance (NMR) spectroscopy and principal component analysis (PCA). Tumor tissue
may also be examined by NMR and PCA.
Identification of metabolomic markers in urine that would assist in identifying higher risk of relapse of Wilms tumor in otherwise lower-risk stratified patients as assessed by NMR spectroscopy and PCA
Dawn Maclellan, MD
IWK Health Centre
United States: Federal Government