Trial Information

Characterization of Urinary Metabolite Profiles in Wilms Tumor

OBJECTIVES:

- To characterize the urinary metabolite signature of 10 stage III, favorable-histology,
Wilms tumor patients from the Cooperative Human Tissue Network (CHTN) Databank, as
distinct from 10 normal controls.

- To characterize and compare the urinary metabolite profile in 50 randomly selected,
stage III, favorable-histology, Wilms tumor patients enriched with an additional 30
stage III Wilms tumor patients who have relapsed.

- To establish if the potential poor outcome (defined as relapse) in the
favorable-histology group has a specific metabolite signature.

- To characterize the urinary metabolite signature of Wilms tumor in patients with
unfavorable histology (diffuse anaplasia) and compare it to those with favorable
histology.

OUTLINE: Archived urine samples are analyzed for specific metabolite patterns by nuclear
magnetic resonance (NMR) spectroscopy and principal component analysis (PCA). Tumor tissue
may also be examined by NMR and PCA.