Inclusion Criteria:

- Participants must be between 18 and 80 years of age

- Participants must be undergoing a major lung resection due to primary or secondary
malignancy

- Must have an aptitude for following directions and commitment to the study

Exclusion Criteria:

- Patients who are unable to read and communicate in English

- Patients undergoing a pneumonectomy or VATS lung resection

- Previous treatments on the same anatomical side including chemotherapy, radiation
therapy, and radio-frequency ablation

- Patients who have undergone decortication for empyema or malignancy.

- Patients who have a chest tube in-situ for persistent air leak

- Patients with clinical or laboratory indicators of renal failure, defined as serum
creatinine level of 170µmol/l

- Patients with active or previous history of peptic ulcer disease

- Patients with a known intolerance to Proton Pump Inhibitors (PPIs)

- Known allergy to study drugs

- Use of NSAIDs 4 weeks prior to randomization or on-going use of NSAIDs.

- The use of any medications known to reduce inflammation, including but not limited
to: steroids (both oral and intravenously), methotrexate, COX-II inhibitors, other
NSAIDs

- Chest tube for persistent air leak.

- Patients who are pregnant or lactating

- Current drug or alcohol use or dependence that, in the opinion of the site
investigator, would interfere with adherence to study requirements.

- Inability or unwillingness of individual or legal guardian/representative to give
written informed consent