Impact of Probiotics on the Intestinal Microbiota and Its Association With Postoperative Outcome After Colorectal Surgery
The intestinal microbiota, a complex and dynamic population of different bacterial species,
under normal circumstances, represents an important contribution to the health of the host.
This plays a key role by maintaining the integrity of the epithelial barrier and helping the
development of mucosal immunity. However, under some stressful situations, such as after
gastrointestinal surgery, infectious complications may be originated from the patient's own
intestinal microbiota. This leads to the so called "gut origin of sepsis" hypothesis. On the
other hand, under similar conditions, the supply of probiotics, the good bacteria, has been
shown to be beneficial, despite few controversial results. Therefore, it is important to
carefully assess the efficacy of probiotics in the prevention and treatment of complications
in surgical patients, as well as to evaluate the safety of its use.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Mucosal cytokine
To assess mucosal cytokine levels
April 2013
No
Brazil: Ethics Committee
CDS - APQ-01005-11
NCT01609660
March 2010
March 2013
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