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Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile


N/A
15 Years
90 Years
Not Enrolling
Both
Diffuse Large B-cell Lymphoma

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Trial Information

Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile


1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay

- Diffuse large B-cell lymphoma patients

- Paraffin-embedded tissue

- End points: Progression-free survival, overall survival

- Statistics: Leave one-out method

2. Nano string assay for microRNA

- Diffuse large B-cell lymphoma patients

- Paraffin-embedded tissue

- End points: Progression-free survival, overall survival

- Statistics: Leave one-out method


Inclusion Criteria:



- Patients diagnosed with diffuse large B-cell lymphoma

- Patients with tissue blocks available for study

- Patients with adequate medical records

Exclusion Criteria:

- Patients diagnosed with other subtypes of lymphoma

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

Number of patients who relapse or progress after 1st line chemotherapy

Outcome Time Frame:

two years

Safety Issue:

No

Principal Investigator

Won Seog Kim, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Samsung Medical Center Cancer Research Institute

Authority:

Korea: Institutional Review Board

Study ID:

2010-05-025

NCT ID:

NCT01606605

Start Date:

January 2011

Completion Date:

December 2012

Related Keywords:

  • Diffuse Large B-Cell Lymphoma
  • Lymphoma
  • Prognosis
  • Relapse
  • Gene
  • microRNA
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse

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