Inclusion Criteria:

1. Histologically proven primary thoracic esophageal squamous cell carcinoma

2. Without chemotherapy or neo-adjuvant chemotherapy in 6 weeks ,radiotherapy has end at
least 1 month,target lesion was not in an irradiated area.

3. Presence of at least one index lesion measurable by CT scan or MRI

4. 18~75 years

5. kps ≥ 70

6. Life expectancy of ≥ 3 months

7. ANC ≥ 2×109/L，PLT ≥ 100×109/L，Hb ≥ 90g/L

8. Cr ≤ 1.0×UNL

9. TB ≤ 1.25×UNL； ALT/AST ≤ 2.5×UNL，THE patient with liver metastasis ALT/AST ≤
5.0×UNL；AKP ≤ 2.5×UNL

10. Signed written informed consent

Exclusion Criteria:

1. Previous exposure to oxa therapy in one year

2. diameter of tumor abdominal ≥ 10cm, Total volumes of liver lesions ≥ 50%,lung
metastasis ≥ 25% total lung

3. chronic diarrhea,enteritis,intestine obstruction which are not under control

4. Psychiatric or addictive disorders that preclude obtaining informed consent or
adherence to protocol.

5. peripheral neuropathy ≥ CTCAE 1

6. Other serious disease

7. Previous or concomitant malignancies except non-melanoma skin cancer, carcinoma in
situ of the cervix, and invasive carcinoma of the colon, thyroid, cervix, or
endometrium treated five years prior to study entry.

8. USE OTHER ANTITUMOR THERAPY

9. Breast-feeding or pregnant women, no effective contraception if risk of conception
exists