Inclusion Criteria:

Subjects must meet all the following criteria to be included in this study:

1. Males and females ≥ 18 years of age

2. Voluntary agreement to provide written informed consent and the willingness and
ability to comply with all aspects of the protocol

3. Life expectancy ≥ 3 months after starting E7016

4. Performance status of 0 - 2 on the Eastern Cooperative Oncology Group (ECOG) scale

5. Histopathologically confirmed diagnosis of melanoma with wt BRAF status (except
melanoma of intraocular origin) with disease progression

6. American Joint Committee on Cancer (AJCC) Stage IV melanoma or unresectable Stage III
melanoma

7. Measurable disease meeting the following criteria:

- At least one lesion of ≥ 1.0 cm in the longest diameter for a non-lymph node or
≥ 1.5 cm in the short-axis diameter for a lymph node which is serially
measurable according to RECIST 1.1 using computerized tomography/magnetic
resonance imaging (CT/MRI). If there is only one target lesion and it is a
non-lymph node, it should have a longest diameter of ≥ 1.5 cm.

- Lesions that have had external beam radiotherapy (EBRT) or loco-regional
therapies such as radiofrequency (RF) ablation must show evidence of progressive
disease based on RECIST 1.1 to be deemed a target lesion.

8. Subjects with brain metastases will be eligible under the following conditions:

- have undergone complete surgical excision and are more than 1 month post-surgery
with no radiographic evidence of disease recurrence in the brain or

- have undergone stereotactic radio surgery (gamma knife procedure or radiotherapy
) and are more than 1 month post procedure and with no radiographic evidence of
disease progression in the brain and

- are asymptomatic and

- discontinued corticosteroid treatment and/or anticonvulsive therapy at least 1
week prior to Cycle 1, Day 1

9. Adequate renal function indicated by serum creatinine < 1.5 mg/dL or calculated
creatinine clearance >50 mL/minute per Cockroft Gault formula

10. Adequate bone marrow reserve:

- Absolute neutrophil count (ANC) ≥ 1500/mm3 (≥ 1.5 x 103/mL)

- Platelets ≥ 100,000/mm3 (without transfusion)

- Hemoglobin ≥ 10 g/dL (< 10.0 g/dL acceptable if corrected by growth factor or
transfusion)

11. Adequate liver function:

- Bilirubin ≤ 1.5 × the upper limit of normal (ULN) except for unconjugated
hyperbilirubinemia of Gilbert's syndrome

- Alkaline phosphatase, alanine aminotransferase (ALT), and aspartate
aminotransferase (AST) ≤ 3 times ULN (≤ 5 × ULN if subject has liver metastases)

12. Left ventricular ejection fraction (LVEF) > 50% on echocardiography or multiple-gated
acquisition (MUGA) scanning

13. Females must not be lactating or pregnant at screening or baseline (as documented by
a negative beta-human chorionic gonadotropin [ß-hCG] test with a minimum sensitivity
of 25 IU/L or equivalent units of ß-hCG). A separate baseline assessment is required
if a negative screening pregnancy test was obtained more than 72 hours before the
first dose of study drug. All females will be considered to be of childbearing
potential unless they are postmenopausal (amenorrheic for at least 12 consecutive
months, in the appropriate age group, and without other known or suspected cause) or
have been sterilized surgically (i.e., bilateral tubal ligation, total hysterectomy,
or bilateral oophorectomy, all with surgery at least 1 month before dosing). Females
of childbearing potential must not have had unprotected sexual intercourse within 30
days prior to study entry and must agree to use a highly effective method of
contraception (e.g., total abstinence, an intrauterine device, a double-barrier
method [such as condom plus diaphragm with spermicide], a contraceptive implant, an
oral contraceptive, or have a vasectomized partner with confirmed azoospermia)
throughout the entire study period and for 30 days after study drug discontinuation.
If currently abstinent, the subject must agree to use a double-barrier method as
described above if she becomes sexually active during the study period or for 30 days
after study drug discontinuation. Females who are using hormonal contraceptives must
have been on a stable dose of the same hormonal contraceptive product for at least 4
weeks prior to dosing and must continue to use the same contraceptive during the
study and for 30 days after study drug discontinuation.

14. Male subjects must have had a successful vasectomy (confirmed azoospermia) or they
and their female partners must meet the criteria above (i.e., not of childbearing
potential or practicing highly effective contraception throughout the study period
and for 30 days after study drug discontinuation).

Exclusion Criteria:

Subjects with any one of the following will be excluded from this study:

1. Subjects with melanoma of intraocular origin

2. Leptomeningeal metastasis or brain metastasis except as for inclusion criteria number
8

3. Subjects taking medications which are either strong CYP inhibitors or inducers

4. Subjects with active malignancies except for wt BRAF Stage IV and unresectable Stage
III melanoma, basal or squamous cell carcinoma of the skin, carcinoma in situ of the
cervix, adequately treated Stage I or II cancer from which the subject is currently
in complete remission, or any other cancer from which the subject has been
disease-free for 5 years

5. Prior treatment with a PARP inhibitor

6. Prior treatment with dacarbazine (DTIC) or TMZ containing regimens

7. Subjects with known allergy, hypersensitivity, or other contraindication to E7016,
TMZ, or DTIC or any of the other components of the formulations

8. Subjects with known human immunodeficiency virus infection (HIV), active hepatitis B
or C

9. Subjects with active infections requiring specific anti-infective therapy

10. Subjects who have had a major surgical procedure (including tumor resection) within 4
weeks prior to initiating E7016 treatment

11. Subjects scheduled for surgery during the projected course of the study

12. Chemotherapy, radiation therapy, or immunotherapy within 4 weeks prior to initiating
E7016 treatment (6 weeks for mitomycin C or nitrosoureas) or any investigational
agent within 30 days prior to the first dose of study drug or who have not recovered
(Grade 0 or 1) from any acute toxicity related to previous anticancer treatment

13. Prolongation of QT corrected, the QT interval corrected for heart rate (QTc) interval
(> 480 ms)

14. Significant cardiovascular impairment: history of congestive heart failure greater
than New York Heart Association (NYHA) Class II ; unstable angina; uncontrolled
hypertension despite optimal treatment, myocardial infarction or stroke within 6
months of the first dose of study drug; or cardiac arrhythmia requiring medical
treatment

15. Subjects with malabsorption syndrome or any other condition that might affect
bioavailability of study drug (E7016 or TMZ)

16. Other relevant disease or adverse clinical conditions such as:

- History of significant neurological (no neuropathy > Grade 2) or psychiatric
disorders

- Significant non-neoplastic liver disease (e.g., cirrhosis, active chronic
hepatitis)

- Significant non-neoplastic renal disease

- Uncontrolled endocrine disease (e.g., diabetes mellitis, hypothyroidism or
hyperthyroidism, adrenal disorder) i.e., requiring relevant changes in
medication within the last month or hospital admission within the last 3 months

17. Any other major illness that, in the investigator's judgment, will substantially
increase the risk associated with the subject's participation in this study

18. Female who are pregnant or breastfeeding