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HPV Types Present in External Genital Warts in the Argentinean Population

15 Years
45 Years
Open (Enrolling)
Condylomata Acuminata

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Trial Information

HPV Types Present in External Genital Warts in the Argentinean Population

This is a prospective study. Patients will be evaluated for the presence of external
anogenital warts in our clinic. Biopsy will be performed if patients have genital lesions
consistent with genital warts of the external genitalia or perianal area. All patients will
be provided with an informed consent for the excision biopsy procedure, before performing
the biopsy of the lesion. Biopsy specimens will be held in a formol 10% solution and will be
sent to the pathologist. A portion of each sample will be processed for histological
analysis, which will be performed by one pathologist. The remainder of each specimen will be
saved to extract DNA for PCR analysis. All biopsies will be analyzed by the same
pathologist who will confirm the histology of the lesion. A part of the specimen will be
kept frozen and if the biopsy confirm genital warts by histology; then the specimen will be
analyzed by PCR for the presence of DNA HPV 6 and 11. The PCR analysis will be done by
microarrays. Detection is performed in a subtype of array platform system which detects the
different types of virus. The reports will be as undetectable / detectable and type.

The study will be conducted in the Institute of Gynecology and Fertility (Institute
affiliated with the School of Medicine - University of Buenos Aires).

Chronogram of activities: all activities will be done in a maximum of 60 days

1. st visit: detect external genital warts and firm informed consent and take the biopsy

2. nd visit: inform the result

Inclusion Criteria:

- women between 15 and 45 years old, with External Genital Warts

Exclusion Criteria:

- women taking corticoid therapy, having an immunosuppressed disease, pregnancy, cancer
related to HPV, VIN confirmed by histology, other sexually transmitted infection,
HIV+ known

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Laura A Fleider, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Buenos Aires


Argentina: Human Research Bioethics Committee

Study ID:

Genital Warts



Start Date:

June 2012

Completion Date:

June 2013

Related Keywords:

  • Condylomata Acuminata
  • genital warts
  • HPV types
  • Sexually Transmitted Diseases
  • Skin Diseases, Viral
  • Tumor Virus Infections
  • Skin Diseases, Infectious
  • Skin Diseases
  • Papillomavirus Infections
  • DNA Virus Infections
  • Virus Diseases
  • Sexually Transmitted Diseases, Viral
  • Condylomata Acuminata