Inclusion Criteria:

- Age over 18 years,

- Patients treated with a first prescription of exclusive oral therapy (chemotherapy
and/or targeted therapy) as part of a cancer,

- Patients who begin treatment with ZYTIGA ® (abiraterone acetate) are incluables,

- Patients with asymptomatic brain metastases are incluables,

- Lack of personality disorders and psychiatric illness scalable,

- Knowledge of spoken and written French,

- Having signed the informed consent of study participation.

Exclusion Criteria:

- Pathology psychiatric

- Refusal to participate,

- Patient unable to respond to cognitive tests, - Documented use of drugs,

- Heavy drinking, - Cancer primitive central nervous system, - Participation in a
clinical trial.