Inclusion Criteria

Inclusion criteria:

1. Histologically/cytologically confirmed hepatocellular carcinoma not amenable to
curative surgery or loco-regional therapy

2. Age 20 years or older

3. Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 or 1

4. Child-Pugh score of 7 or less

5. Life expectancy more than 3 months

6. Time interval from last loco-regional therapy more than 4 weeks

7. Written informed consent in accordance with good clinical practice (GCP)

Exclusion criteria:

1. More than one line of prior systemic therapy for metastatic/unresectable
hepatocellular carcinoma (HCC)

2. Fibrolamellar HCC

3. Uncontrolled or refractory ascites

4. Inadequate organ function

5. Variceal bleeding within 6 months or the presence of inappropriate varices

6. History of major thrombotic (except portal vein thrombosis) or clinically relevant
major bleeding event in the past 6 months

7. Major surgery within 4 weeks

8. Known inherited predisposition to bleeding or thrombosis

9. Significant cardiovascular diseases