Inclusion Criteria:

- Pathologically confirmed adenocarcinoma of the pancreas

- Unresectable locally advanced disease base on institutional standard criteria of
unresectability disease following radical surgery. There is no evidence of metastatic
disease in the major viscera and no peritoneal seeding

- Patients with biliary or gastroduodenal obstruction must have drainage prior to
starting chemoradiation

- All malignant disease must be encompassable within a single irradiation field
(15x15cm maximum)

- All patients must have radiographically assessable disease

- No previous irradiation to the planned field

- Age of ≥ 18 years

- performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG) score

- Required Entry Laboratory Parameters WBC count ≥ 1,000/mm3; hemoglobin level ≥ 7.5
g/dL; platelet count ≥ 100,000/mm3; total bilirubin ≤ 3.0 mg/dL (Patients with
elevated bilirubin due to obstruction should be stented and their bilirubin should be
decrease ≤ 3.0 mg/dL prior to study entry); creatinine ≤ 3.0 mg/dL

- Oral intake (including J-tube feeding) of ≥ 1,500 calories/day should be maintained.

- Signed informed consent form prior to study entry

Exclusion Criteria:

- There is evidence of metastasis in the major viscera or peritoneal seeding.

- Age of < 18 years

- Previous history of RT adjacent to planned field

- Poor performance status of 2 to 4 on the Eastern Cooperative Oncology Group (ECOG)
score

- Pregnant or breast feeding status

- Previous history of uncontrolled other malignancies within 2 years