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Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer


N/A
21 Years
70 Years
Open (Enrolling)
Female
Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer

Thank you

Trial Information

Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer


Inclusion Criteria:



- diagnosed with stage I-IV ovarian, peritoneal or fallopian tube cancer

- completed first-line taxane and platinum-based chemotherapy 1-4 months prior to being
enrolled in the study (can be on bevacizumab maintenance)

- in remission of their disease at the time of enrollment between 21 and 70 years of
age

- fluent in English

- in the judgment of the consenting professional, have capacity to give consent

Healthy Control

Inclusion Criteria:



- no diagnosis of cancer except basal cell carcinoma

- between 21 and 70 years of age

- fluent in English

- has a mini-mental state exam (MMSE) score of 26 or higher

- in the judgment of the consenting professional, have capacity to give consent

Exclusion Criteria:

- active or recurrent disease, or diagnosis of another cancer (except basal cell
carcinoma) as per medical records at the time of enrollment

- exposure to chemotherapy or radiation therapy for any medical condition unrelated to
ovarian cancer

- on hormonal therapy at the time of enrollment

- neurological disorder or moderate to severe head trauma (loss of consciousness > 60
min)

- neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis, etc.

- self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia

- unable to complete cognitive tests

- with standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

- exposure to chemotherapy or radiation therapy for any medical condition

- on hormone replacement therapy at the time of enrollment

- neurological disorder or moderate to severe head trauma (loss of consciousness > 60
min)

- neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease,
multiple sclerosis, etc.

Type of Study:

Observational

Study Design:

Observational Model: Case-Crossover, Time Perspective: Prospective

Outcome Measure:

alterations in regional brain volume

Outcome Description:

will undergo structural MRI scans on a Siemens 3T Magnetom Tim Trio research scanner located at the Citigroup Biomedical Imaging Center at Weill Cornell Medical Center (WCMC), which is adjacent to the MSKCC campus. Three to five T1 weighted sagittal slices are collected to localize the anterior and posterior commissures. Functional imaging: Blood Oxygenation Level-Dependent (BOLD) contrast imaging, which reflects changes in venous deoxyhemoglobin associated with neuronal activity, will be used.

Outcome Time Frame:

1 year

Safety Issue:

No

Principal Investigator

Denise Correa, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

12-075

NCT ID:

NCT01591772

Start Date:

April 2012

Completion Date:

April 2014

Related Keywords:

  • Fallopian Tube Cancer
  • Ovarian Cancer
  • Peritoneal Cancer
  • FALLOPIAN TUBE
  • OVARY
  • PERITONEUM
  • Quality of Life
  • structural MRI
  • functional MRI
  • neuropsychological assessment
  • 12-075
  • Ovarian Neoplasms
  • Peritoneal Neoplasms
  • Fallopian Tube Neoplasms

Name

Location

Memorial Sloan Kettering Cancer Center New York, New York  10021
Weill Cornell Medical Center New York, New York  10021