Cardiac-Sparing Whole Lung IMRT in Children and Young Adults With Lung Metastases: A Feasibility Study
I. To demonstrate the feasibility of delivering cardiac-sparing IMRT in a
multi-institutional setting with central quality control for children and young adults with
metastatic tumors in the lungs.
II. To prospectively determine the dosimetric advantages of whole lung IMRT treatment over
standard whole lung irradiation by comparing treatment plans and different organ dose-volume
histograms such as lungs, heart, thyroid gland, liver etc. in all patients enrolled in this
III. To determine the short-term efficacy (lung-metastases free survival) and acute
tolerance of whole lung IMRT at a minimum period of six months after IMRT.
Patients undergo cardiac-sparing whole lung IMRT.
After completion of study treatment, patients are followed up for 1-5 years.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Feasibility of delivering cardiac-sparing IMRT with central quality control in 20 subjects
Feasibility of delivering whole lung IMRT will be demonstrated by obtaining QARC central quality control approval of institutional IMRT plans for the 20 subjects enrolled onto the study.
United States: Institutional Review Board
|Ann & Rober H Lurie Children's Hospital of Chicago||Chicago, Illinois 60611|