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Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma


N/A
N/A
N/A
Open (Enrolling)
Both
Sarcoma

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Trial Information

Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma


OBJECTIVES:

- To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to
establish a more accurate estimate of the frequency of particular genetic lesions.

- To provide the statistical power to establish an unambiguous connection between focal
genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma.

OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated
from previous discovery. DNA is then eluted and sequenced by illumina platform.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Matched genomic deoxyribonucleic acid (DNA) from tumor and germline samples from
patients diagnosed with rhabdomyosarcoma (alveolar or embryonal)

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Frequency of particular genetic lesions

Safety Issue:

No

Principal Investigator

Alberto S. Pappo, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital

Authority:

United States: Federal Government

Study ID:

CDR0000732173

NCT ID:

NCT01585376

Start Date:

April 2012

Completion Date:

Related Keywords:

  • Sarcoma
  • alveolar childhood rhabdomyosarcoma
  • embryonal childhood rhabdomyosarcoma
  • Rhabdomyosarcoma
  • Sarcoma

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