Study Recurrency Testing of Mutations Identified in WGS of Pediatric Rhabdomyosarcoma
OBJECTIVES:
- To obtain a larger cohort of rhabdomyosarcoma samples (alveolar and embryonal) to
establish a more accurate estimate of the frequency of particular genetic lesions.
- To provide the statistical power to establish an unambiguous connection between focal
genetic lesions, histological subtype, and outcome for patients with rhabdomyosarcoma.
OUTLINE: DNA samples are analyzed in solid and liquid phase for exons of all genes mutated
from previous discovery. DNA is then eluted and sequenced by illumina platform.
Observational
N/A
Frequency of particular genetic lesions
No
Alberto S. Pappo, MD
Principal Investigator
St. Jude Children's Research Hospital
United States: Federal Government
CDR0000732173
NCT01585376
April 2012
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