Inclusion Criteria:

- Histological or cytological documentation of adenocarcinoma of the colon or rectum.
All other histological types are excluded.

- Subjects with metastatic colorectal cancer(CRC) (Stage IV).

- Subjects must have failed at least two lines of prior treatment.

- Progression during or within 3 months following the last administration of approved
standard therapies which must include a fluoropyrimidine, oxaliplatin and irinotecan.

- Subjects treated with oxaliplatin in an adjuvant setting should have progressed
during or within 6 months of completion of adjuvant therapy.

- Subjects who progress more than 6 months after completion of oxaliplatin
containing adjuvant treatment must be retreated with oxaliplatin-based therapy
to be eligible.

- Subjects who have withdrawn from standard treatment due to unacceptable toxicity
warranting discontinuation of treatment and precluding retreatment with the same
agent prior to progression of disease will also be allowed into the study.

- Subjects may have received prior treatment with Avastin (bevacizumab) and/or
Erbitux (cetuximab)/Vectibix (panitumumab) (if KRAS WT)

- Metastatic CRC subjects must have measurable or non measurable disease according to
Response Evaluation Criteria in Solid Tumors (RECIST) criteria, version 1.1.

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 1.

- Life expectancy of at least 3 months.

- Adequate bone marrow, liver and renal function as assessed by the laboratory required
by protocol.

Exclusion Criteria:

- Prior treatment with Regorafenib.

- Previous or concurrent cancer that is distinct in primary site or histology from
colorectal cancer within 5 years prior to randomization EXCEPT for curatively treated
cervical cancer in situ, non-melanoma skin cancer and superficial bladder tumors [Ta
(non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor invades lamina propria)].

- Extended field radiotherapy within 4 weeks or limited field radiotherapy within 2
weeks prior to randomization.

- Cardiological disease including Congestive heart failure, Unstable angina, Myocardial
infarction, Cardiac arrhythmias requiring anti-arrhythmic therapy.

- Uncontrolled hypertension. (Systolic blood pressure 150 mmHg or diastolic pressure 90
mmHg despite optimal medical management).

- Subjects with phaeochromocytoma.

- Pleural effusion or ascites that causes respiratory compromise.

- Arterial or venous thrombotic or embolic events.

- Any history of or currently known brain metastases.

- Interstitial lung disease with ongoing signs and symptoms at the time of informed
consent.

- Systemic anticancer therapy including cytotoxic therapy, signal transduction
inhibitors, immunotherapy, and hormonal therapy during this trial or within 4 week.