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Endoscopic Ultrasound Predict the Sensitivity of Stage II / III Rectal Cancer Preoperative Concurrent Chemoradiotherapy


N/A
18 Years
75 Years
Open (Enrolling)
Both
Rectal Cancer

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Trial Information

Endoscopic Ultrasound Predict the Sensitivity of Stage II / III Rectal Cancer Preoperative Concurrent Chemoradiotherapy


We use endoscopic ultrasound to measure the primary tumor maximum diameter changes to
predict the tumor regression after concurrent chemoradiotherapy for rectal cancer


Inclusion Criteria:



- pathologically confirmed rectal cancer, preoperative stage II / III (T3-4N0 or T1-4N
+ M0).

- tumor distance from anus less than 12 cm.

- KPS score not less than 70

- can be tolerated chemotherapy and radiotherapy.

- pelvic who had no history of radiation therapy.

- Non-allergic history of fluorouracil or platinum-based chemotherapy drugs.

- a full understanding of the study, the ability to complete all of the treatment plan,
follow up the conditions and sign the informed consent.

Exclusion Criteria:

- other malignancy (past or at the same time), does not include curable non-melanoma
skin cancer and cervical carcinoma in situ; does not include resectable primary colon
cancer (synchronous or metachronous).

- pregnant or lactating patients.

- fertility but did not use contraceptive measures.

- existing active infection.

- merge serious complications, can not tolerate the treatment, such as 6 months of
myocardial infarction, mental illness, uncontrollable diabetes or uncontrollable
hypertension or hypotension.

- concurrent treatment with other anticancer drugs.

- can not complete treatment or follow-up.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Endoscopic ultrasound measurement of the primary tumor maximum diameter changes in absolute / relative values

Outcome Time Frame:

3 months

Safety Issue:

No

Principal Investigator

Jing Jin, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Chinese Acedemy of Medical Sciences

Authority:

China: Ministry of Health

Study ID:

CH-RO-GI-eus

NCT ID:

NCT01582750

Start Date:

October 2010

Completion Date:

December 2015

Related Keywords:

  • Rectal Cancer
  • endoscopic ultrasound
  • pre-operative concurrent chemoradiotherapy
  • Rectal Neoplasms

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