Inclusion Criteria:

- Histologically proven epidermoid carcinoma of the anus

- Locally advanced tumour without metastases

- Stage T2>3 cm or T3 or T4, irrespective of N

- Stage N1-N3 irrespective of T stage (T1 to T4)

- General condition WHO 0-1

- Life expectancy > 3 months

- Signed informed consent form

- Age > 18 years

- Effective contraception in female and/or male patients having reached sexual maturity
during treatment and up to 6 months after the end of treatment

- CD4 > 400 / mm3

- Measureable tumor on at least one of the following exams : MRI, endoscopic
ultrasonography, clinical exam

Exclusion Criteria:

- Presence of metastases

- Previous anti-EGFR therapy

- Stage T1N0 or T2 < 3 cm N0

- History of pelvic radiotherapy

- At least one of the following laboratory test results: Neutrophils < 1500 /mm3,
platelets < 100 000 /mm3, Hb < 9 g/dl, leukocytes < 3000/mm3, blood bilirubin > 1.5
times the upper limit of the normal range, transaminase (ASAT and ALAT) > 2.5 times
the upper limit of the normal range, creatinine clearance < 50 mL/min (Cockcroft's
formula Appendix x), Mg2+ < the lower limit of the normal range, Ca2+ < the lower
limit of the normal range

- Significant coronary artery disease or myocardial infarction in the past year

- Follow-up not possible due to psychological or geographic reasons

- History of interstitial pneumonitis or pulmonary fibrosis

- History of malignant disease in the past five years apart from basocellular skin
carcinoma or in situ cervical carcinoma having received adequate treatment

- Pregnant or breast-feeding women, women of child-bearing potential not having taken a
pregnancy test.