Inclusion Criteria:

1. Patients with advanced, metastatic and/or progressive solid tumours for whom there is
no effective standard therapy available.

2. Evaluable or measurable disease

3. Has normal organ functions; is no greater than 2 on the ECOG Performance Scale

4. life expectancy of >3 months

5. negative hCG test in women of childbearing potential

Exclusion Criteria:

1. Patients who received an investigational anti-cancer drug within 4 weeks of starting
the study

2. Patients who received major surgery, radiotherapy, or immunotherapy within 4 weeks of
starting the study

3. Clinically significant, unresolved toxicity from previous anti-cancer therapy
Patients

4. Patients who previously received a MEK inhibitor

5. Presence of active gastrointestinal disease or other condition that will interfere
significantly with the absorption, distribution, metabolism, or excretion of drugs.

6. Known medical history of retinal vein occlusion, intraocular pressure greater than 21
mm Hg or patient considered at risk of retinal vein thrombosis.

7. Known HIV positivity or active hepatitis B or C infection.

8. History of clinically significant cardiac condition