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Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers


N/A
18 Years
85 Years
Open (Enrolling)
Both
Lung Neoplasms

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Trial Information

Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung and Other Thoracic Cancers


To identify baseline and treatment-related somatic changes in the tumor tissue from patients
with lung and other thoracic cancers. To estimate the proportion of patients that
subsequent therapy is altered based on the information acquired from such biopsies.


Inclusion Criteria:



1. Patients undergoing investigation or treatment for thoracic cancers with
oncogene-targeted therapies

2. Aged 18 years or older

3. Either be:a) have suspected tumor progression or other condition that dictates a
standard-of-care palliative, therapeutic, or diagnostic intervention including but
not limited to procedures such as bronchoscopic biopsy, CT or US-guided biopsy,
thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy,
adrenalectomy or pleural catheter placement, providing tumor specimen appropriate
molecular analysis or b) have previously had biopsy/surgical intervention with tumor
tissue at University of Colorado or an outside institution available for medullar
analysis.

4. Patients must have the ability to understand and willingness to sign an informed
consent document.

-

Exclusion Criteria:

-

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Outcome Measure:

To identify baseline and treatment-related somatic changes in the tumor tissue from patients with lung and other thoracic cancers.

Outcome Time Frame:

To be determined upon funding

Safety Issue:

No

Principal Investigator

Robert C. Doebele, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Colorado, Denver

Authority:

United States: Institutional Review Board

Study ID:

11-1621

NCT ID:

NCT01580982

Start Date:

December 2011

Completion Date:

May 2014

Related Keywords:

  • Lung Neoplasms
  • Oncogenes
  • Lung and Other Thoracic Cancers
  • Neoplasms
  • Lung Neoplasms

Name

Location

University of Colorado Cancer CenterDenver, Colorado  80262