Inclusion Criteria:

1. Patients undergoing investigation or treatment for thoracic cancers with
oncogene-targeted therapies

2. Aged 18 years or older

3. Either be:a) have suspected tumor progression or other condition that dictates a
standard-of-care palliative, therapeutic, or diagnostic intervention including but
not limited to procedures such as bronchoscopic biopsy, CT or US-guided biopsy,
thoracentesis, video assisted thoracoscopic (VATS) pleurodesis, lobectomy,
adrenalectomy or pleural catheter placement, providing tumor specimen appropriate
molecular analysis or b) have previously had biopsy/surgical intervention with tumor
tissue at University of Colorado or an outside institution available for medullar
analysis.

4. Patients must have the ability to understand and willingness to sign an informed
consent document.

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Exclusion Criteria:

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