Assessment of a Consensus Driven Narrow Band Imaging (NBI) Pattern Classification System in Barrett's Esophagus (BE)
This is a multicenter, prospective, double-blinded study of NBI images from 50 patients
enrolled in the study. Patients undergoing BE screening and BE surveillance will be enrolled
into the study. After meeting eligibility criteria, and obtaining an informed consent,
patients will undergo their routine upper endoscopic examination using white light
endoscopy. During the course of the upper endoscopy, the BE surface patterns will be
carefully examined with the endoscope in overview mode (with the endoscope in the center of
the esophageal lumen) and then in close proximity to the BE surface (approximately 3-5 mm
away from the mucosa). In each of these positions, a maximum of 4 high quality images will
be obtained from different surface patterns initially with WLE and then using NBI. Image
capture will be standardized. All the images will be classified based upon a simplified NBI
classification system using two main criteria:(1)mucosal
pattern(regular/irregular/uncertain) and (2)vascular pattern (regular/irregular/uncertain).
All images will be captured using a high-definition, NBI endoscope (190 endoscopes-GIF-HQ
190 [dual focus],Olympus Inc) and stored in the high quality TIFF format. After images have
been obtained, target biopsies will be obtained from each area and submitted for
histopathological evaluation in separate jars. From the reports on NBI patterns from the
images by Gastroenterologist and corresponding histopathological details, the accuracy and
interobserver agreement of this NBI classification system will be determined.
Observational Model: Case Control, Time Perspective: Prospective
Determine the inter-observer agreement of a consensus driven NBI classification system in Barrett's esophagus.
Identifying newer consensus driven NBI classification system in Barrett's esophagus for better inter observer agreement among experts and community/general gastroenterologists. Higher interobserver agreement (measured by Landis and Koch method) on these NBI patterns in Barrett's esophagus will help in diagnosing dysplasia in an uniform way among the gastroenterologists.
Prateek Sharma, MD
Kansas City VA Medical Center
United States: Federal Government
|The University of Chicago Medical Center||Chicago, Illinois 60637-1470|
|Kansas City VA Medical Center||Kansas City, Missouri 64128|