Inclusion Criteria:

- Patients age: ≥ 18 years

- Undergoing endoscopy for surveillance or endoscopic treatment of Barrett's esophagus

- Ability to take oral proton pump inhibitor

- For female subjects of childbearing potential, a negative urine pregnancy test within
2 weeks of enrollment and any subsequent endoscopy encounter

- Subject is eligible for treatment and follow-up endoscopy and biopsy as required by
the investigational plan

- Ability to discontinue Aspirin/NSAIDs/Clopidogrel 7 days before and after all
ablation procedures

- Ability to provide written, informed consent and understands the responsibilities of
trial participation

Exclusion Criteria:

- The subject is pregnant or planning a pregnancy during the study period (12 months
after treatment)

- Esophageal stricture preventing passage of endoscope or catheter

- Active erosive esophagitis

- Prior endoscopic therapy with endoscopic mucosal resection, radiofrequency ablation,
etc.

- History of esophageal varices or coagulopathy

- Prior radiation therapy to the esophagus, except head and neck region radiation
therapy.

- Evidence of esophageal varices during treatment endoscopy

- Subject has a known history of unresolved drug or alcohol dependency that would limit
ability to comprehend or follow instructions related to informed consent,
post-treatment instructions, or follow-up guidelines

- The subject is currently enrolled in an investigational drug or device trial that
clinically interferes with the current study.

- Subject suffers from psychiatric or other illness deemed by the investigator as an
inability to comply with protocol