The Neurobiology of Chemotherapy-Induced Cognitive Impairment
Chemotherapy has been linked to cognitive impairments among breast cancer patients,
especially in the domains of executive function (planning and problem solving), attention,
learning, and information processing. The etiology of these chemotherapy-associated
impairments remains unknown, although recent neuroimaging studies suggest that disruption of
white matter integrity may play a role. With continued use of chemotherapy in breast cancer
patients, this study's novel use of functional neuroimaging will be significant to better
inform practitioners and patients of potential consequences to anticipate and serve as a
starting point in the development of therapeutic interventions.
Observational Model: Case Control, Time Perspective: Cross-Sectional
Changes in fractional anisotropy (FA) in one or more white matter tracts.
As compared with the controls, the breast cancer patients will show decreased fractional anisotropy (FA) in the frontal and temporal white matter (WM) tracts and.
post-chemotherapy. One time measure within one year of final dose of chemotherapy.
Jay F. Piccirillo, MD
Washington University School of Medicine
United States: Institutional Review Board
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