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Investigating the Frequency of Loss of Imprinting Across a Birth Cohort and the Link DNA Methylation Plays


N/A
N/A
21 Years
Open (Enrolling)
Both
Kidney Cancer

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Trial Information

Investigating the Frequency of Loss of Imprinting Across a Birth Cohort and the Link DNA Methylation Plays


OBJECTIVES:

- What is the frequency of loss of imprinting at birth (in the cord blood and placenta)
in a relatively healthy birth cohort?

- Does deoxyribonucleic acid (DNA) methylation levels at imprinting genes have a direct
association to the gene expression?

OUTLINE: Archived tumor tissue, cord blood, and placenta samples are analyzed for DNA
methylation, single nucleotide polymorphism, and gene expression by polymerase chain
reaction (PCR), pyrosequencing, and quantitative real-time PCR. Information regarding gender
and age of the samples are also collected, if possible.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Wilms tumor tissue samples from Caucasians (fresh or frozen), or DNA and ribonucleic
acid (RNA) samples already isolated from patients registered on Children's Oncology
Group Wilms tumor protocols

- Normal/control blood samples from matched individuals

- Cord blood/ placenta samples from the Michels lab Epigenetic Birth Cohort

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Frequency of loss of imprinting at birth

Safety Issue:

No

Principal Investigator

Karin Michels, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dana-Farber/Brigham and Women's Cancer Center

Authority:

United States: Federal Government

Study ID:

CDR0000730596

NCT ID:

NCT01576211

Start Date:

April 2012

Completion Date:

Related Keywords:

  • Kidney Cancer
  • Wilms tumor and other childhood kidney tumors
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Wilms Tumor

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