Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood. Ancillary Study of the "Long-term Follow-up of Childhood Cancer Survivors in the Rhône-Alpes and Auvergne Regions of France" Study
For this purpose, analysis of the cardiac RR variability is a reliable, non-invasive and
reproducible system that could be used in this population as a tool for early detection of
cardiovascular dysfunction.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Autonomic nervous system activity
The autonomic status will be classified in sympatho-vagal equilibrium as "normal", "altered" or "severely abnormal" according to the values obtained for some temporal indices (SDNN, SDaNN, RMSSD etc. ..) and frequencies (Ptot, HF, LF , VLF, ratio LF / HF) compared to validated standards for the age (mean +/- standard deviation).
15 years after the end of the cancer treatment
No
Claire BERGER, MD
Principal Investigator
CHU de Saint-Etienne
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
1108162
NCT01574196
September 2012
March 2014
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