Trial Information
DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood
OBJECTIVES:
- To assess the role of DICER1 mutations and miRNA pathways in the etiology and
progression of ovarian or testicular sex cord stromal tumors.
OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression
by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector.
Results are then correlated with medical data, including age at diagnosis, diagnosis,
pathology report, presenting symptoms, family history, treatment, outcome, and length of
follow-up, when available.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the
International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and
Massachusetts General Hospital
- Tissue samples from patients diagnosed with:
- Ovarian
- Sertoli-Leydig cell tumor
- Juvenile granulosa cell tumor
- Adult granulosa cell tumor
- Gynandroblastoma
- Sex cord stromal tumor with annular tubules
- Sex cord stromal tumor, undifferentiated
- Sertoli tumor
- Leydig tumor
- Testicular:
- Granulosa cell tumor
- Sertoli tumor
- Leydig tumor
- Sertoli-Leydig
- Undifferentiated stromal tumor
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis
Safety Issue:
No
Principal Investigator
Dana A. Hill, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Children's Research Institute
Authority:
United States: Federal Government
Study ID:
CDR0000730091
NCT ID:
NCT01572467
Start Date:
April 2012
Completion Date:
Related Keywords:
- Childhood Germ Cell Tumor
- Leydig Cell Tumor
- Ovarian Cancer
- Leydig cell tumor
- ovarian stromal cancer
- childhood malignant testicular germ cell tumor
- childhood malignant ovarian germ cell tumor
- Leydig Cell Tumor
- Ovarian Neoplasms
- Neoplasms, Germ Cell and Embryonal
- Sex Cord-Gonadal Stromal Tumors