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DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood


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Open (Enrolling)
Both
Childhood Germ Cell Tumor, Leydig Cell Tumor, Ovarian Cancer

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Trial Information

DICER1 Mutations and miRNA in Ovarian and Testicular Sex Cord Stromal Tumors of Childhood


OBJECTIVES:

- To assess the role of DICER1 mutations and miRNA pathways in the etiology and
progression of ovarian or testicular sex cord stromal tumors.

OUTLINE: Archived tumor tissue samples are analyzed for D1CER1 mutation and mRNA expression
by reverse-transcriptase polymerase chain reaction (RT-PCR) and laser micro dissector.
Results are then correlated with medical data, including age at diagnosis, diagnosis,
pathology report, presenting symptoms, family history, treatment, outcome, and length of
follow-up, when available.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Fixed and frozen tissue samples from the ATBR01 B1 tissue bank and from the
International Pleuropulmonary Blastoma Registry, Children's Hospital of Boston, and
Massachusetts General Hospital

- Tissue samples from patients diagnosed with:

- Ovarian

- Sertoli-Leydig cell tumor

- Juvenile granulosa cell tumor

- Adult granulosa cell tumor

- Gynandroblastoma

- Sex cord stromal tumor with annular tubules

- Sex cord stromal tumor, undifferentiated

- Sertoli tumor

- Leydig tumor

- Testicular:

- Granulosa cell tumor

- Sertoli tumor

- Leydig tumor

- Sertoli-Leydig

- Undifferentiated stromal tumor

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Correlation between DICER1 mutations and miRNA pathways with outcomes using descriptive analysis

Safety Issue:

No

Principal Investigator

Dana A. Hill, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Children's Research Institute

Authority:

United States: Federal Government

Study ID:

CDR0000730091

NCT ID:

NCT01572467

Start Date:

April 2012

Completion Date:

Related Keywords:

  • Childhood Germ Cell Tumor
  • Leydig Cell Tumor
  • Ovarian Cancer
  • Leydig cell tumor
  • ovarian stromal cancer
  • childhood malignant testicular germ cell tumor
  • childhood malignant ovarian germ cell tumor
  • Leydig Cell Tumor
  • Ovarian Neoplasms
  • Neoplasms, Germ Cell and Embryonal
  • Sex Cord-Gonadal Stromal Tumors

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