Inclusion Criteria

- INCLUSION CRITERIA:

- Age: Patients must be > than 12 months and less than or equal to 21 years of age at
the time of study enrollment.

- Diagnosis: Patients with refractory or recurrent solid tumors, including lymphomas,
without CNS tumors or known CNS metastases are eligible for the initial dose
escalation phase (Part A). Once the MTD or recommended phase 2 dose has been defined,
patients with CNS tumors or known CNS metastases may enroll in the expanded cohort
(Part B). All patients must have had histologic verification of malignancy at
original diagnosis or relapse except patients with intrinsic brain stem tumors, optic
pathway gliomas, or patients with pineal tumors and elevations of CSF or serum tumor
markers including alphafetoprotein or beta-HCG.

- Disease Status: Patients must have either measurable or evaluable disease

- Therapeutic Options: Patient's current disease state must be one for which there is
no known curative therapy or therapy proven to prolong survival with anacceptable
quality of life.

- Performance Level: Karnofsky greater than or equal to 50% for patients > 16 years of
age and Lansky greater than or equal to 50 for patients less than 16 years of age.
Note: Neurologic deficits in patients with CNS tumors must have been relatively
stable for a minimum of 1 week prior to study enrollment. Patients who are unable to
walk because of paralysis, but who are up in a wheelchair, will be considered
ambulatory for the purpose of assessing the performance score.

Prior Therapy

- Patients must have fully recovered from the acute toxic effects of all prior anti-cancer
chemotherapy, immunotherapy, or radiotherapy.

1. Myelosuppressive chemotherapy: Must not have received

myelosuppressive chemotherapy within 3 weeks of enrollment onto this study (6 weeks
if prior nitrosourea).

2. Hematopoietic growth factors: At least 14 days after the last dose of a long-acting
growth factor (e.g. Neulasta) or 7 days for short-acting growth factor. For agents
that have known adverse events occurring beyond 7 days after administration, this
period must be extended beyond the time during which adverse events are known to
occur. The duration of this interval must be discussed with the study chair.

3. Biologic (anti-neoplastic agent): At least 7 days after the last dose of a biologic
agent. For agents that have known adverse events occurring beyond 7 days after
administration, this period must be extended beyond the time during which adverse
events are known to occur. The duration of this interval must be discussed with the
study chair.

4. Immunotherapy: At least 6 weeks since the completion of any type of immunotherapy,
e.g. tumor vaccines.

5. Monoclonal antibodies: At least 3 half-lives of the antibody after the last dose of a
monoclonal antibody.

6. XRT: greater than or equal to 2 weeks for local palliative XRT (small port); :
greater than or equal to 24 weeks must have elapsed if prior TBI, craniospinal XRT or
if : greater than or equal to 50% radiation of pelvis; greater than or equal to 6
weeks must have elapsed if other substantial BM radiation.

7. Stem Cell Infusion without TBI: No evidence of active graft vs. host disease and :
greater than or equal to 12 weeks must have elapsed since transplant or stem cell
infusion. Patients with prior allogeneic transplants are not eligible.

Organ Function Requirements

- Adequate Bone Marrow Function Defined as:

1. For patients with solid tumors without known bone marrow involvement:

- Peripheral absolute neutrophil count (ANC) : greater than or equal to 1000/mm(3)

- Platelet count : greater than or equal to 100,000/mm(3) (transfusion
independent, defined as not receiving platelet transfusions within a 7 day
period priorto enrollment)

2. Patients with known bone marrow metastatic disease will be eligible for study
provided they meet the blood counts in

-.a (may receive transfusions provided they are not known to be refractory to red
cell or platelet transfusions). These patients will not be evaluable for hematologic
toxicity. At least 5 of every cohort of 6 patients with a solid tumor must be
evaluable for hematologic toxicity. If dose-limiting hematologic toxicity is
observed, all subsequent patients enrolled must be evaluable for hematologic
toxicity.

- Adequate Renal Function Defined as:

- Creatinine clearance or radioisotope GFR greater than or equal to 70ml/min/1.73
m(2) or

- A serum creatinine based on age/gender as follows:

Age Maximum Serum Creatinine (mg/dL)

Male Female

1 to < 2 years 0.6 0.6

2 to < 6 years 0.8 0.8

6 to < 10 years 1 1

10 to < 13 years 1.2 1.2

13 to < 16 years 1.5 1.4

greater than or equal to 16 years1.7 1.4

- Adequate Liver Function Defined as:

- Bilirubin (sum of conjugated + unconjugated) less than or equal to 1.5 x upper
limit of normal (ULN) for age

- SGPT (ALT) less than or equal to 110 U/L. For the purpose of this study, the ULN
for

SGPT is 45 U/L.

- Serum albumin greater than or equal to 2 g/dL

Adequate Coagulation Defined as:

- aPTT < 1.2 x ULN

Informed Consent: All patients and/or their parents or legally authorized
representatives must sign a written informed consent. Assent, when appropriate, will
be obtained according to institutional guidelines.

EXCLUSION CRITERIA:

- Pregnancy or Breast-Feeding

Pregnant or breast-feeding women will not be entered on this study, because there is
yet no available information regarding human fetal or teratogenic toxicities.
Pregnancy tests must be obtained in girls who are post-menarchal. Males or females of
reproductive potential may not participate unless they have agreed to use an
effective contraceptive method.

Concomitant Medications

- Corticosteroids: Patients receiving corticosteroids who have not been on a stable
or decreasing dose of corticosteroid for the prior 7 days are not eligible.

- Investigational Drugs: Patients who are currently receiving another investigational
drug are not eligible.

- Anti-cancer Agents: Patients who are currently receiving other anticancer agents
are not eligible.

- Anti-GVHD or agents to prevent organ rejection post-transplant:

Patients who are receiving cyclosporine, tacrolimus or other agents to prevent either
graft-versus-host disease post bone marrow transplant or organ rejection post
transplant are not eligible for this trial.

- Infection: Patients who have an uncontrolled infection are not eligible.

- Prior or current CNS bleed (Part B): Patients with CNS tumors or known CNS
metastases who have imaging evidence of a prior or current CNS hemorrhage on the
baseline MRI obtained within 14 days prior to study enrollment are not eligible.
Note: The presence of small punctate areas consistent with hemorrhage on ECHO
gradient MRI sequences will not exclude patients from participation.

- Patients with prior allogeneic transplants are not eligible.

- Patients who in the opinion of the investigator may not be able to comply with
the safety monitoring requirements of the study are not eligible.