Tissue Acquisition for Analysis of Prognostic Factors, Immunology, and Genetic Progression of HIV-1 Associated Malignancies
- To obtain high-quality, clinically annotated tissue from patients with human
immunodeficiency virus (HIV)-1 malignancy.
- To study clinical, genetic, and immunologic parameters that have prognostic
significance and/or are involved in the initiation and progression of HIV-1
malignancies, including complete genomic sequence determination of HIV-associated
diffuse large B-cell lymphomas, lung cancer, anal cancer, and cervical cancer.
OUTLINE: This is a multicenter study.
Patients undergo tumor, lymph node, bone marrow, or skin biopsy, and peripheral blood
mononuclear cells collection. Samples are submitted to the AIDS Malignancy Consortium (AMC)
Biorepository and transferred to the AIDS and Cancer Specimen Resource (ACSR). Samples are
then analyzed by the Genome Science Center of British Columbia (GSC-BC) and the HIV+ Tumor
Molecular Characterization Project (HTMCP) for full genomic sequencing analysis that may
include, but are not limited to, array-based gene expression profiling, comparative genome
hybridization, and single nucleotide polymorphism studies by flow cytometry, cytogenetics,
and molecular studies. Patients' clinical data, demographics, and treatment given are also
collected prospectively in order to record treatment outcome and toxicity.
Patients are followed up at 6 months, 1 year, and 2 years for data-reporting purposes.
Observational Model: Cohort, Time Perspective: Prospective
Mutational spectrum of each type of HIV-1 associated malignancy
Complete genomic sequencing of HIV-1 associated tumor tissue
Study entry (prior to chemotherapy initiation)
Lee Ratner, MD, PhD
Washington University Siteman Cancer Center
United States: Federal Government
|Cancer Research Center of Hawaii||Honolulu, Hawaii 96813|
|Albert Einstein Cancer Center at Albert Einstein College of Medicine||Bronx, New York 10461|
|UCLA Clinical AIDS Research and Education (CARE) Center||Los Angeles, California 90024|
|University of Miami||Miami, Florida 33136|
|AIDS Associated Malignancies Clinical Trials Consortium||Saint Louis, Missouri 63110|