Inclusion Criteria:

- histologically confirmed adenocarcinoma in colorectal cancer

- clinical stage Ⅲ or Ⅳa(with potential radical resective metastatic lesions),≥ 12
lymph nodes examined

- no cancer cells were found in ascites

- Eastern Cooperative Oncology Group(ECOG) performance status of 0-2

- male or female, between 18 and 75 years old

- adequate hematologic, hepatic and renal functions

- without severe heart disease in the last 6 months before enrolled. If with
hypertension or coronary artery disease, it can be controlled

- not enrolled into others clinical trial during this study

- all patients should sign the informed consent

Exclusion Criteria:

- can not be tolerated operation

- receiving others therapy(including Traditional Chinese herbs)for this disease, can
not obey the investigator during the study

- can not be tolerated the adverse effect of drugs in these regimens

- major surgery within 4 weeks prior to study treatment start, or lack of complete
recovery from major surgery

- metastatic disease more than one organ

- pregnant or lactating women