Determining the Cell of Origin and Prognostic Gene Signatures in SWOG Trials of Diffuse Large B-Cell Lymphoma
- To determine the proportion of the cell of origin subtypes (germinal center B-cell-like
[GCB] vs non-GCB) and expression levels of prognostic genes previously identified in
diffuse large B-cell lymphoma (DLBCL) in patient biopsy samples from SWOG trials of
limited- and advanced-stage DLBCL, and to assess the association between the results
and progression-free survival (PFS).
- To assess the association between these marker results and overall survival (OS).
OUTLINE: Archived formalin-fixed paraffin-embedded tissue are analyzed for gene expression
profile by quantitative nuclease protection assay (qNPA) and immunohistochemical analyses.
Results are then compared with each patient's progression-free survival and overall
Proportion of GCB phenotype among limited-stage vs advanced-stage patients
Daniel O. Persky, MD
University of Arizona