Inclusion Criteria:

- Histologically documented CD20 and CD22 positive diffuse large B-cell lymphoma,
according to WHO classification. CD20 and CD22 immunophenotyping at initial diagnosis
is acceptable. If such prior documentation is not available, then the
immunophenotyping at relapse must be established by fine-needle aspirate or biopsy
or by circulating CD20 and CD22 positive NHL cells from peripheral blood during
screening. Upon registration the pathological report confirming the diagnosis, must
be available

- In first or second relapse or refractory to first and/or second line treatment.
Refractory is defined as having exhibited less than or PR to a prior rituximab
containing regimen or having relapsed within 6 months of the last dose of a prior
rituximab containing regimen.

- Measurable disease by bidimensional transverse CT scan assessment

- Not eligible for autologous transplantation.

- Previously treated with a chemotherapy regimen containing anthracyclines and
rituximab.

- Aged 18 - 80 years.

- ECOG performance status 0 to 2.

- Minimum life expectancy of 3 months.

- Signed written informed consent.

Exclusion Criteria:

- Burkitt, mantle cell and T-cell lymphomas.

- Central nervous system or meningeal involvement by the lymphoma.

- Contraindication to any drug contained in the R-GEMOX combination chemotherapy.

- Treatment with any investigational drug within 30 days before the first planned cycle
of chemotherapy and during the study.

- Nitrosurea or mitomycin C administration within 6 weeks prior to study start.

- Major debulking surgery within 3 weeks of treatment.

- Any of the following lab abnormalities (unless related to the lymphoma or bone marrow
infiltration):

Absolute neutrophil count (ANC) < 1.500/µL (1,5.109/L).

Platelet count < 100.000/µL (100.109/L).

Creatinin level > 150 µmol/L (1,7 mg/dL) or 1,5 - 2,0x ULN.

Total bilirubin level > 30 µmol/L (1,8 mg/dL) or 1,5x ULN.

Serum AST/SGOT or ALT/SGPT >2,5x ULN.

- Documented infection with HIV, active hepatitis B or C infection.

- Any serious active disease or co-morbid medical condition that, according to the
investigator's decision, will substantially increase the risk associated with the
subject's participation in the study. Prior history of malignancies other than
lymphoma with the exception of non-melanoma skin tumors (basal cell or squamous cell
carcinoma of the skin) or stage 0 (in situ) cervical carcinoma unless the subject has
been disease-free for 5 or more years..

- LVEF less than 50% (measured by echocardiography or scintigraphy).

- Previous myocardial infarction or pulmonary hypertension within 6 months before the
first dose of investigational product.

- Congestive heart failure NYHA stage III or IV

- Known chronic liver disease (eg. Cirrhosis) or suspected alcohol abuse.

- Pregnant or lactating females

- Men and women who are biologically capable of having children not willing to use an
adequate method of birth control during the study and up to 18 months after the last
dose of investigational product.

- Adult patient unable to provide informed consent because of intellectual impairment,
any serious medical condition, laboratory abnormality or psychiatric illness.