Inclusion Criteria:

1. Age ≥ 18 years.

2. DLBCL and MCL diagnosed patients in primary resistance or relapsed not eligible for
intensification chemotherapy followed by Autologous stem cell transplantation (ASCT)
for age, comorbidity or previous ASCT.

3. Any IPI or ECOG, capable of understanding the nature of the trial.

4. Writtern Informed Consent.

Exclusion Criteria:

1. Nursing pregnant or lactation period women, or fertile age adults not using
effective contraceptive method.

2. CNS lymphoma patients.

3. Patients with severa renal (creatinine> 2,5 UNL) or hepatic (Bilirrubin or ALT/AST>
2,5 UNL) impairement not provided by the same disease

4. HIV positive patients.

5. Serious psychiatric diseases patients that could interfere with their skill to
understand the study (including alcoholism or drug addiction).

6. Murine proteins or any other component of the medicines of the study hypersensitivity
patients.

7. Patients who have received more than 2 therapeutic previous lines. (for previous ASCT
patients, induction and conditioning for the TAPH treatment is considered a single
line therapy).