Role of Proteasomes in a Dermatological Autoimmune Disease: Bullous Pemphigoid
The secondary objectives of this study are:
To compare the following parameters between the 3 groups:
- plasmatic proteasome concentrations
- plasmatic proteasome proteolytic activity
To explore the potential relationships between:
- plasmatic proteasome concentrations
- plasmatic proteasome proteolytic activity
- plasmatic anti-proteasome auto-antibody concentrations
- measures of disease severity for dermatological auto-immune diseases
To characterize plasmatic anti-proteasome auto-antibodies in patients suffering from bullous
pemphigoide and other dermatological auto-immune diseases (other bullous auto immune
diseases: pemphigus, cutaneous lupus, ...).
To characterize the expression and the activity of proteasomes in skin samples, in plasma
and in circulating mononuclear cells in patients with bullous pemphigoide.
Observational
Observational Model: Cohort, Time Perspective: Cross-Sectional
Plasmatic concentration of anti-proteasome autoantibodies (ng/ml)
baseline
No
Pierre Stoebner, MD
Principal Investigator
Centre Hospitalier Universitaire de Nîmes
France: Committee for the Protection of Personnes
LOCAL/2011/PS-02
NCT01559155
July 2013
July 2015
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