Inclusion Criteria:

1. Signed written informed consent.

2. 18 years of age or older.

3. Medically fit patients without relevant comorbidity, defined as total CIRS score ≤
6.

4. WHO performance status of 0-2.

5. Confirmed diagnosis of CLL in need of treatment (Binet C or A/B with active disease)
according to the updated IWCLL guidelines (Hallek et al. 2008).

6. Life expectancy > 12 weeks.

7. Relapsed or refractory disease after at least one, but no more than 3 prior regimens.
Patients who previously received bendamustine (with or without rituximab) must have
had at least a partial response with duration of response of at least six months.

8. CLL therapy, major surgery, or irradiation for CLL was completed > 4 weeks before
registration in this study. Patients must have recovered from the acute side effects
incurred as a result of previous therapy.

9. Patient is able and willing to receive adequate anticoagulation as specified in this
protocol.

10. Adequate liver function as indicated by a total bilirubin, AST, and ALT ≤2 the
institutional ULN value, unless directly attributable to the patient's tumor.

11. Creatinine clearance >60ml/min calculated according to the modified formula of
Cockcroft and Gault or directly measured after 24h-urine collection.

12. ANC > 1500/µl and platelet count > 75.000/μl, unless decrease is due to bone marrow
involvement of CLL

13. Negative serological hepatitis B test, negative testing of hepatitis C RNA, negative
HIV test within 6 weeks prior to registration.

14. Females of childbearing potential (FOCP) must understand that the study medication
has a teratogenic risk and must agree to use, and be able to comply with effective
contraception without interruption, 4 weeks before starting study drug, throughout
study drug therapy (including dose interruptions) and for 6 months after the end of
study drug therapy, even if she has amenorrhea. This applies unless the subject
commits to absolute and continued abstinence confirmed on a monthly basis.

Exclusion Criteria:

1. Previously treated with > 3 prior regimens for CLL.

2. Known central nervous system (CNS) involvement of CLL.

3. Patients who have progressed with more aggressive B-cell cancers such as Richter's
syndrome or are diagnosed with B-PLL.

4. History of anaphylaxis following exposure to any of the used study-drugs and/or
thalidomide.

5. Evidence of TLS per the Cairo-Bishop definition of laboratory TLS (subjects may be
enrolled upon correction of electrolyte abnormalities).

6. Participation in another clinical trial and/or use of investigational agents or
concurrent anti cancer treatment within the last 4 weeks of registration.

7. Other severe, concurrent diseases, including tuberculosis, mental disorders, serious
cardiac functional capacity (class III or IV as defined by the New York Heart
Association Classification), severe diabetes, severe hypertension, pulmonary disease
(COPD with hypoxemia), or major organ malfunction that could interfere with the
patient's ability to participate in the study.

8. Pregnant or lactating women.

9. Any circumstance at the time of study entry that would preclude completion of the
study or the required follow-up.

10. Active secondary malignancy requiring treatment (except basal cell carcinoma or
malignant tumor curatively treated by surgery) within the last 5 years before
registration.

11. Active bacterial, viral or fungal infection.

12. Medical condition requiring prolonged use of oral corticosteroids (> 1 month).

13. Cerebral dysfunction, legal incapacity.

14. Patients with contraindications according to Summary of Product Characteristics or
Investigator's Brochure.

15. Patients who are employees of the Sponsor (University of Cologne) or the study sites.

16. Persons placed in an institution by legal or official order.