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The Role of Stroma-Derived Soluble TßRIII in Neuroblastoma


N/A
N/A
21 Years
Open (Enrolling)
Both
Neoplastic Syndrome, Neuroblastoma

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Trial Information

The Role of Stroma-Derived Soluble TßRIII in Neuroblastoma


OBJECTIVES:

- Determine whether TβRIII expression and TGF-β signaling decrease in advanced-stage
neuroblastoma (NBL) and whether these changes are confined to the Schwannian stroma.

- Determine whether sTβRIII levels and TGF-β signaling correlate with NBL stage, tumor
stroma content, surface TβRIII expression, and TGF-β signaling.

OUTLINE: Archived paraffin-embedded tissue and plasma samples are analyzed for TβRIII
expression, TGF-β signaling, and SMAD3 expression and phosphorylation by
immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and other assays. Surface
expression of TβRIII in the neuroblastic and stromal tumor components are correlated with
matched circulating levels of soluble TβRIII. Results are then correlated with each
patient's outcome data, including stage.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Tissue samples and matched plasma samples available from 1 of the following groups:

- Patients with low-stage (International Neuroblastoma Staging System [INSS] stage
1 or 2) neuroblastoma (NBL)

- Patients with advanced-stage (INSS stage 3 or 4) NBL

- Patients with stage 4S NBL

- Clinical and/or outcome data associated with the tissue and plasma samples including
INSS stage, age, MYCN amplification status, chromosomal alterations, and 5-year
survival, if known

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Expression of TβRIII in the neuroblastic tumor and stroma of patients with advanced-stage NBL

Safety Issue:

No

Principal Investigator

Gerard C. Blobe, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Duke University

Authority:

United States: Federal Government

Study ID:

CDR0000728527

NCT ID:

NCT01553448

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Neoplastic Syndrome
  • Neuroblastoma
  • disseminated neuroblastoma
  • hereditary neuroblastoma
  • localized resectable neuroblastoma
  • localized unresectable neuroblastoma
  • stage 4S neuroblastoma
  • Neoplasms
  • Neuroblastoma

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