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Determination of the Frequency of BRG1 and BRM Loss in Rhabdoid Tumors


N/A
N/A
N/A
Open (Enrolling)
Both
Brain and Central Nervous System Tumors, Kidney Cancer

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Trial Information

Determination of the Frequency of BRG1 and BRM Loss in Rhabdoid Tumors


OBJECTIVES:

- To determine if BRM is silenced in the majority, if not all, rhabdoid tumors by
immunohistochemistry in primary tumors.

- To determine if BRG1 is silenced in the majority, if not all, rhabdoid tumors by
immunohistochemistry in primary tumors.

- To determine if GATA1 and/or HDAC2 is overexpressed in the same tumors that lack BRM
expression.

- To determine if BRM promoter polymorphisms correlate with loss of BRM expression in
primary rhabdoid tumors.

- To determine how BRG1 is silenced in primary rhabdoid tumors by sequencing BRG1 exons
in genomic DNA derived from frozen samples.

OUTLINE: Archived tumor tissue samples are analyzed for BRM, BRG1, GATA1, and/or HDAC2
expression by immunohistochemistry. BRM- and BRG1-negative samples are also analyzed.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Tumor samples from patients diagnosed with rhabdoid tumors

- Matched frozen tumor tissue from BRG1-negative tumors (preferred) or matched genomic
DNA from tumors, 100 ng per tumor from BRG1-negative tumors

- Any source of DNA from BRG1-negative tumors (tumors, blood, etc.)

- Matched frozen tumor tissue from BRM-negative tumors to confirm that BRM is not
mutated or altered but rather epigenetically suppressed when lost in rhabdoid tumors

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Absence or presence BRG1 and BRM expression in rhabdoid tumors

Safety Issue:

No

Principal Investigator

David Reisman, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Florida

Authority:

United States: Federal Government

Study ID:

CDR0000728521

NCT ID:

NCT01553175

Start Date:

March 2012

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • Kidney Cancer
  • childhood atypical teratoid/rhabdoid tumor
  • rhabdoid tumor of the kidney
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms
  • Rhabdoid Tumor

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