B-precursor Acute Lymphoblastic Leukemia (ALL): Studying the Mechanisms Behind Dexamethasone and Prednisone Sensitivity in High-Risk Patients
1 Year
21 Years
Both
Leukemia
Trial Information
B-precursor Acute Lymphoblastic Leukemia (ALL): Studying the Mechanisms Behind Dexamethasone and Prednisone Sensitivity in High-Risk Patients
OBJECTIVES:
- Identify differences in the effect of dexamethasone (Dex) and prednisone (Pred) on
glucocorticoid receptor (GR) occupancy and gene expression in high-risk (HR) B-cell
precursor (BCP)-acute lymphoblastic leukemia (ALL) samples from patients aged 1-9.
- Identify differences in gene expression and GR occupancy of response elements in HR
BCP-ALL patients > 10 years old in response to both Dex and Pred.
OUTLINE: Archived samples are analyzed for gene expression analysis and genomic location of
glucocorticoid receptor by ChIP sequencing (ChiPseq) and RNA sequencing. Data of gene
expression and ChiPseq data sets are compared by luciferase reporter assay.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients diagnosed with high-risk B-cell precursor acute lymphoblastic leukemia
- Samples from patients treated and not treated with Dex and Pred
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Differentially expressed genes from both HR BCP-ALL patients aged 1-9 and patients over 10 years old
Safety Issue:
No
Principal Investigator
Miles A. Pufall, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
University of Iowa
Authority:
United States: Federal Government
Study ID:
CDR0000728515
NCT ID:
NCT01553162
Start Date:
March 2012
Completion Date:
Related Keywords:
- Leukemia
- B-cell childhood acute lymphoblastic leukemia
- untreated childhood acute lymphoblastic leukemia
- Leukemia
- Leukemia, Lymphoid
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
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