Inclusion Criteria:

Histologic and radiographic proof of localized high-risk soft tissue sarcoma meeting the
following criteria:

- Lesion originates in extremity

- upper extremity lesions may occur from the medial border of the scapula to
tumors as far distal as the finger tips

- lower extremity regions include hip girdle tumors commencing at the iliac crest,
excluding lesions arising from within the pelvis, and extends to include lesions
as far distal as the toes

- AJCC Stage II or III disease (except T1a-tumors or N1)

- Primary presentation or local recurrence

- after biopsy or inadequate surgery resulting in residual tumor in cross-sectional
imaging

- Tumors must be considered resectable according to cross sectional imaging, or
potentially resectable after preoperative radiotherapy

- ECOG Performance Status 0-2

- Informed Consent

Exclusion Criteria:

- Diagnosis of the following:

- Primitive neuroectodermal tumor

- Soft tissue Ewing`s sarcoma

- Extraskeletal osteo- or chondrosarcoma

- Aggressive fibromatosis (desmoid tumors)

- Dermatofibrosarcoma protuberans

- Regional nodal disease or unequivocal distant metastasis

- Life expectancy < 1 year

- Pregnancy

- Major medical illness that would preclude study treatment

- History of major wound complication or recurrent skin infection

- Known HIV positivity

- < 2 weeks elapsed from prior surgery or cytotoxic chemotherapy

- persisting acute toxicities > grade 1 in tumor-bearing limb resulting from prior
treatment with anti-cancer modalities

- Cytotoxic chemotherapy, targeted therapy or investigational agents concurrent to
study treatment

- Prior radiotherapy to the site of present STS.

- Chronic requirement for treatment with immuno¬suppressive agents or steroids.