Inclusion Criteria:

- Male or female from 1 to 17 year-old, inclusive.

- Confirmed relapsed/refractory leukemia or lymphoma to the last regimen, and the
patient is without standard therapy for the disease.

- For subjects aged <16 years, modified Lansky Play Performance Scale (Appendix A) of
40% or above; For subjects aged ≥16 years, Karnofsky Performance Status (Appendix B)
of 40% or above.

- For lymphoma patients, at least one node or nodal mass is measurable by CT scan.

- Willing to adhere to the prohibitions and restrictions specified in this protocol.

- Subject's legally acceptable representative must has signed an informed consent
document and patient aged 7 or above must provide an assenting signature on the
informed consent document, indicating that he/she/they understand(s) the purpose of
and procedures required for the study and is willing to participate in the study.

Exclusion Criteria:

- Has received cancer treatment, e.g. chemotherapy, targeted biologic or enzymes,
either approved or investigational, within 2 weeks prior to the start of the
PEG-BCT-100.

- Any toxic effects (except hair loss) of the prior therapy have not been resolved to
Grade 2 or less according to National Cancer Institute (NCI) Common Terminology
Criteria for Adverse Events.

- Total bilirubin > 1.5 x ULN not related to hemolysis or Gilbert's disease, and
AST/ALT > 5 x ULN

- Serum creatinine > 2 x ULN or calculated creatinine clearance < 60 ml/min.

- Any other active malignancy within the past year except basal cell or squamous cell
skin cancer or carcinoma in situ of the cervix or breast.

- Uncontrolled intercurrent illness including, but not limited to symptomatic
congestive heart failure, unstable angina pectoris or cardiac arrhythmia.

- History of HIV-1 seropositivity.

- Active infection not adequately responding to appropriate therapy.

- Female patient is pregnant or lactating.

- Female patient with childbearing potential and sexual activity who does not agree or
unable to use adequate contraceptive [including prescription oral contraceptives
(birth control pills), contraceptive injections, intrauterine device (IUD),
double-barrier method (spermicidal jelly or foam with condoms or diaphragm),
contraceptive patch, or surgical sterilization] before entry and throughout the
study.

- Male patient with sexual activity who does not agree to use adequate contraception
(barrier method of birth control in conjunction with spermicidal jelly) prior to
study entry and throughout the study.

- Use of any investigational drug(s) within 2 weeks prior to the start of the
PEG-BCT-100.

- Use of any arginine depleting agent within 2 weeks prior to the start of the
PEG-BCT-100.

- Subjects, who in the opinion of the Investigator, are unable to comply with the trial
treatment and the related trial procedures.